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Pragmatic trials are those that are designed to provide information for the practice of clinical trials in real life. They are typically characterized by a focus on the practical aspects of the study design, such as the recruitment process and consent as well as adherence to the use of commonly available equipment.
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A pragmatic study that involves a variety investigators and includes participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is required for pragmatic trials to be able to prove their validity, and it also helps to reduce the chance of bias in the results. However too much heterogeneity could lead to problems with the design of the trial.
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Mobile compatibility
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Legality
Pragmatic Play has earned a name for itself by providing top-notch games and an exceptional user experience. The software is available on mobile devices and in multiple languages. Despite its relatively young age it has already established itself as a leading gaming platform for casinos. Wolves is one of its latest releases which is a five-reel slot machine that has a high RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.
Pragmatic trials seek to replicate real-life settings and achieve maximum external validity. They are typically commissioned by practitioners and policy makers to aid in their decision-making. They are also a good way to identify the causal relationship between an intervention and its outcomes. However, they should not be used in lieu for the use of explanation studies.
The pragmatism idea is controversial, and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which support the validity of a physiological or clinical hypothesis, and pragmatic trials that aid in the decision-making process for policy and practice. Highly recommended Internet site proposed a framework for pragmatic trials, which they called PRECIS.2 This tool sought to define the characteristics of a practical trial which includes the recruitment process, the design and delivery of the intervention, as well as monitoring.
The number of pragmatic trials is growing. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs) resulted in 34 articles, shown in red in Figure 2. This indicates that the health sciences community is becoming more sensitive to the issue of pragmatics. It is important to note that the majority of these trials were conducted in primary care settings.